Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fusion inhibitors.

J Petrik1

  • 1Scottish National Blood Transfusion Service, LCMV Royal (Dick) Veterinary College, Summerhall, Edinburgh, EH9 1QH, UK. juraj.petrik@snbts.csa.scot.nhs.uk

Idrugs : the Investigational Drugs Journal
|July 16, 2003
PubMed
Summary

Current antiviral drugs targeting replication or maturation face resistance issues. Novel fusion inhibitors offer a new strategy by blocking virus entry into host cells, potentially overcoming resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study.

Alimentary pharmacology & therapeutics·2015
Same author

Evaluation of a potassium removal filter on irradiated red cells stored in SAGM.

Transfusion medicine (Oxford, England)·2015
Same author

Storage of apheresis platelet concentrates after manual replacement of >95% of plasma with PAS 5.

Vox sanguinis·2014
Same author

Hepatitis E virus in Scottish blood donors.

Vox sanguinis·2013
Same author

Novel approaches to antiviral and anticancer immunotherapy.

Acta virologica·2012
Same author

[Benefits of sentinel lymph node examination in early breast carcinoma].

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2011

Area of Science:

  • Virology
  • Drug Discovery
  • Molecular Biology

Background:

  • Most antiviral medications target viral replication or maturation.
  • These drugs often lead to drug-resistant mutants and incomplete viral elimination.
  • Combination therapies show limited success in overcoming resistance.

Purpose of the Study:

  • To explore novel antiviral strategies targeting earlier stages of the viral lifecycle.
  • To investigate virus entry inhibitors, specifically fusion inhibitors, as a potential therapeutic approach.

Main Methods:

  • Review of existing antiviral drug mechanisms.
  • Focus on the mechanism of action of fusion inhibitors.
  • Analysis of fusion inhibitors' role in blocking viral entry.

Main Results:

  • Current antivirals primarily target reverse transcriptase and protease enzymes.
  • Drug resistance is a significant limitation of current antiviral therapies.
  • Fusion inhibitors represent a promising class of antivirals targeting the virus-host membrane fusion process.

Conclusions:

  • Fusion inhibitors offer a novel therapeutic avenue by inhibiting viral entry.
  • Targeting the virus-host membrane fusion step may circumvent existing resistance mechanisms.
  • Further research into fusion inhibitors could lead to more effective antiviral treatments.

Related Experiment Videos