Related Experiment Video
Updated: Jul 24, 2026

Linear Amplification Mediated PCR – Localization of Genetic Elements and Characterization of Unknown Flanking DNA
Published on: June 25, 2014
Accidental germ-line modifications through somatic cell gene therapies: some ethical considerations
1Philosophy Department, 801 McClung Tower, University of Tennessee, Knoxville, TN 37996-0480, USA. jkaplan@utk.edu
Abstract:
Proposed somatic cell gene-therapies (especially those involving in utero therapies) may involve a small risk of germ-line modifications; this risk has engendered serious concern, and arguments have been made that such therapies ought not be pursued if such risks exists. We argue here that while pursuing deliberate germ-line modifications in humans would be inappropriate given the current state of the art, the risk of accidental germ-line modifications from most currently proposed in utero gene therapy is no different in kind or degree from other risks regularly taken in medical procedures. Given the possible benefits of such therapies, we argue that the risk of accidental germ-line modifications is well worth taking in these cases.
Related Concept Videos
What is Genetic Engineering?
Gene Therapy
Gene Therapy
Induced Pluripotent Stem Cells
Somatic cells are...
Somatic to iPS Cell Reprogramming
Methods of Nuclear Reprogramming

