Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fatal abdominal thorotrast granuloma.

H Ishii1, A Tanaka, Y Nakayama

  • 1Division of Internal Medicine, Moji Rosai Hospital, Kitakyushu, Japan.

Internal Medicine (Tokyo, Japan)
|October 1, 1992
PubMed
Summary

A rare abdominal thorotrast granuloma, developing 49 years after a procedure, caused fatal ureteral obstruction, venous thrombosis, and organ perforation. This case highlights the severe, long-term risks of thorotrast exposure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peroxisomal acetoacetyl-CoA thiolase of an n-alkane-utilizing yeast, Candida tropicalis.

European journal of biochemistry·1992
Same author

Isolation and characterization of cDNAs from BamHI-H gene family RNAs associated with the tumorigenicity of Marek's disease virus.

Journal of virology·1992
Same author

Studies on antiplatelet agents. I. Synthesis and platelet inhibitory activity of 5-alkyl-2-aryl-4-pyridylimidazoles.

Chemical & pharmaceutical bulletin·1992
Same author

Physiological roles of acetoacetyl-CoA thiolase in n-alkane-utilizable yeast, Candida tropicalis: possible contribution to alkane degradation and sterol biosynthesis.

Journal of biochemistry·1992
Same author

Analyses of the risk and operative stress for donors in living-related partial liver transplantation.

Transplantation·1992
Same author

Cloning and characterization of the secY gene from the cyanobacterium Synechococcus PCC7942.

Biochimica et biophysica acta·1992

Area of Science:

  • Radiology and Pathology
  • Toxicology and Long-term Health Effects

Background:

  • Thorotrast, a historically used radiographic contrast agent, poses long-term health risks due to its radioactive nature.
  • Delayed complications from thorotrast deposition can manifest decades after exposure.

Observation:

  • A 65-year-old man presented with symptoms stemming from a large abdominal thorotrast granuloma.
  • The granuloma developed 49 years after accidental extravasation during a femoral angiography procedure.

Findings:

  • The growing thorotrast granuloma led to critical complications, including ureteral obstruction, venous thrombosis, and perforation of the urinary bladder and rectum.
  • This represents the first documented instance of a thorotrast granuloma causing perforation through both the urinary bladder and rectum.

Related Experiment Videos

Implications:

  • This case underscores the critical importance of recognizing the potential for severe, delayed complications from historical thorotrast use.
  • It highlights the need for vigilance in diagnosing and managing rare granulomatous diseases, even many years after initial exposure.
  • The findings emphasize the severe morbidity associated with thorotrast-induced granulomas, particularly when they lead to organ perforation.