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High transfection efficiency of poly(4-vinylimidazole) as a new gene carrier
Jong-Eun Ihm1, Ki-Ok Han, In-Kwon Han
1School of Agricultural Biotechnology, Seoul National University, Suwon 441-744, Korea.
Abstract:
Poly(4-vinylimidazole) (P4V) was obtained by free radical polymerization of 4-vinylimidazole (4V) prepared by decarboxylation of urocanic acid. P4V formed a complex with DNA that exhibited higher transfection effiency on Hela cells than polyethylenimine (PEI), through the proton sponge mechanism of the imidazole groups in the side chain of the P4V, and low cell toxicity.
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