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Recent Progress of Dopamine-Modified Tissue Adhesives for Biomedical Applications in Underwater Environments
Chong-Su Cho1, Gi-Yeon Han2, Eun Byul Koh1
1Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Tissue Engineering and Regenerative Medicine
|March 19, 2026
Summary
Mussel-inspired catechol chemistry offers advanced underwater adhesion solutions, overcoming water
Area of Science:
- Materials Science
- Biomaterials Engineering
- Surface Chemistry
Background:
- Underwater adhesion is crucial for applications like wound dressings and biosensors.
- Interfacial water weakens adhesion, limiting current adhesive technologies in wet environments.
Purpose of the Study:
- To review catechol-based underwater adhesion technologies.
- To discuss dopamine-modified tissue adhesives (TAs) and their properties.
Main Methods:
- Literature review of PubMed database up to April 2025.
- Focus on mussel-inspired catechol-based adhesion strategies.
Main Results:
- Mussel-inspired catechol-based TAs show promise due to strong interfacial interactions.
- Dopamine (DA)-modified TAs offer diverse designs and excellent underwater adhesion.
Conclusions:
- Catechol-based TAs present a viable strategy for robust underwater bonding.
- Challenges and future directions for stimuli-responsive and DA-modified TAs are explored.
