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Features of serum beta-lipoprotein electrophoretogram in patients with coronary heart disease

Yun-qin Chen1, Jia Yin, Min Zhang

  • 1Electrocardiology Research Center, Department of Basic Science, First Military Medical University, Guangzhou 510515, China. SLPG@fimmu.edu.cn

Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA
|July 17, 2003
PubMed

Insights

Elevated beta-lipoprotein (beta Lp) subfraction beta Lp1 is a key indicator in patients with coronary heart disease (CHD). This finding aids in understanding CHD biomarkers and diagnosis.

Area of Science:

  • Cardiovascular Research
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Coronary heart disease (CHD) is a significant global health concern.
  • Lipoprotein profiles are crucial in assessing cardiovascular risk.
  • Specific alterations in beta-lipoprotein (beta Lp) subfractions may serve as diagnostic markers for CHD.

Purpose of the Study:

  • To investigate alterations in the serum beta-lipoprotein (beta Lp) electrophoretogram of patients diagnosed with coronary heart disease (CHD).
  • To identify specific beta Lp subfractions that are indicative of CHD.

Main Methods:

  • Serum samples were analyzed from 36 CHD patients, 28 non-CHD patients, and 8 healthy controls.
  • Beta-lipoproteins were isolated using double-gradient polyacrylamide gel electrophoresis (DGPAGE).
  • Quantitative analysis of four beta Lp subfractions (beta Lp1-4) was performed, alongside serum low-density lipoprotein cholesterol (LDLc) measurements.

Main Results:

  • A significant elevation in the relative amount of beta Lp1 was observed in CHD patients (53.4+/-10.0%) compared to normal subjects (39.3+/-6.7%) and non-CHD patients (42.8+/-6.8%).
  • This increase in beta Lp1 was independent of serum LDLc concentrations.
  • No significant difference in beta Lp1 content was found between normal and non-CHD patient groups.

Conclusions:

  • An imbalance in serum beta Lp subfractions, specifically an increased level of beta Lp1, characterizes patients with CHD.
  • Elevated beta Lp1 may serve as a potential biomarker for the diagnosis of coronary heart disease.
Abstract

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