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[The exfoliation or pseudo-exfoliation syndrome]
1Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou.
Summary
Pseudo-exfoliation syndrome (PE) is rare in China. Early signs include pupillary pigment loss and trabecular meshwork pigmentation, with dandruff-like particles and lens ring being typical findings.
Area of Science:
- Ophthalmology
- Pathology
Context:
- Pseudo-exfoliation syndrome (PE) is exceptionally rare in the Chinese population.
- This study investigates the clinical and histopathologic characteristics of PE in 13 Chinese patients.
Purpose:
- To describe the early and typical clinical manifestations of pseudo-exfoliation syndrome.
- To elucidate the histopathologic nature of the pseudo-exfoliative material in the anterior segment of the eye.
Summary:
- Early clinical signs of PE include overlooked pupillary ruff pigment loss and dense trabecular meshwork pigmentation.
- Typical findings encompass dandruff-like particles on the pupillary margin and a greyish-white ring at the lens's anterior periphery.
- Histopathology reveals PAS-positive amorphous material composed of fibrils accumulating in the anterior eye segment.
Impact:
- Highlights subtle early diagnostic signs of PE, potentially improving early detection rates.
- Provides valuable histopathologic insights into the composition and distribution of pseudo-exfoliative material.
- Contributes to understanding the geographic variability and clinical presentation of this rare ocular condition.