[The ultrastructural changes in the glomeruli and juxtaglomerular apparatus at different periods of endotoxic shock]

It is shown that after endotoxin injection the ultrastructural changes in the glomeruli can favour development of the acute renal insufficiency. In the initial and intermediate periods of the endotoxin shock the granular and agranular forms of juxtaglomerular cells hyperfunction, respectively, are revealed as well as an increase of renin activity in plasma. At the stage of the late endotoxemia ultrastructural alterations are stabilized. The juxtaglomerular cells synthesize and accumulate secretory granules, but renin activity in plasma decreases almost to the initial level.