Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of glucocorticoids on bone density.

Qaiser Rehman1, Nancy E Lane

  • 1South Central Kansas Bone and Joint Center, Pratt, Kansas 67124, USA. qrehman@prmc.org

Medical and Pediatric Oncology
|July 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning-based effusion-synovitis volume measured on MRI is associated with osteoarthritis progression: A longitudinal analysis of data from the osteoarthritis initiative.

Osteoarthritis and cartilage open·2026
Same author

Association of Intramuscular Fat Infiltration With Incident Venous Thromboembolism: A Population-Based Cohort Study.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Deep learning-based quantification of knee effusion-synovitis volume on MRI - Technique development and validation.

Osteoarthritis and cartilage·2026
Same author

Elevated Serum CXCL9 Levels Are Associated with Greater Frailty Risk in Older Women.

Endocrinology and metabolism (Seoul, Korea)·2026
Same author

Association between central obesity and MRI-based biomarkers of knee osteoarthritis independent of BMI: A cross-sectional study from the Osteoarthritis Initiative database.

Osteoarthritis and cartilage open·2026
Same author

Sex- and site-specific associations between hemoglobin levels and cortical bone structure and microarchitecture in older adults.

Bone·2026

Glucocorticoid therapy causes secondary osteoporosis by reducing bone formation and increasing bone resorption. Future treatments aim to restore hormonal balance to prevent bone loss.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • Glucocorticoid therapy is a leading cause of iatrogenic osteoporosis.
  • Bone loss results from decreased bone formation and increased bone resorption.
  • Glucocorticoids impact osteoblast and osteoclast activity.

Purpose of the Study:

  • To elucidate the mechanisms of glucocorticoid-induced bone loss.
  • To identify therapeutic targets for glucocorticoid-induced osteoporosis.

Main Methods:

  • Review of existing literature on glucocorticoid effects on bone metabolism.
  • Analysis of the role of the RANKL-OPG system, gonadal hormones, and calcium balance.

Main Results:

  • Glucocorticoids induce osteoblast apoptosis and enhance osteoclast survival.

Related Experiment Videos

  • The RANKL-OPG system is a key mediator of these effects.
  • Hormonal imbalances and calcium dysregulation contribute to bone loss.

    • Conclusions:

    • Understanding glucocorticoid's impact on bone cell apoptosis and survival is crucial.
    • Therapeutic strategies should focus on restoring hormonal and cytokine balance.
    • Targeting the apoptotic effects of glucocorticoids may prevent bone loss.