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[Glucose intolerance in obese children: a preliminary study].

Salesa Barja1, M Isabel Hodgson, Ana M Acosta

  • 1Departamento de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile. sbarja@puc.cl

Revista Medica De Chile
|July 23, 2003
PubMed
Summary

Obese children with glucose intolerance (GI) show reduced insulin secretion, not increased insulin resistance (IR), despite similar clinical features. This suggests impaired insulin production contributes to GI in pediatric obesity.

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Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Obesity Research

Context:

  • Childhood obesity is rising, increasing the risk of Type 2 Diabetes Mellitus.
  • Glucose intolerance (GI) is a precursor to Type 2 Diabetes, following a period of insulin resistance (IR).
  • Understanding metabolic characteristics in obese children is crucial for early intervention.

Purpose:

  • To characterize the clinical and metabolic profiles of obese children based on their glucose tolerance status.
  • To investigate differences in insulin resistance and secretion between obese children with and without GI.

Summary:

  • A study of 52 obese children (ages 8-17) assessed glucose tolerance and insulin dynamics using an oral glucose tolerance test and HOMA index.
  • Children with GI (11.5%) exhibited similar clinical features and HOMA scores to those with normal glucose tolerance.

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  • However, children with GI had lower 30-minute insulin levels, a reduced Insulinogenic Index, and higher total and LDL cholesterol.

    • Impact:

    • Identifies decreased insulin secretion as a key factor in the development of glucose intolerance in severely obese children with IR.
    • Highlights the need for monitoring lipid profiles in obese children.
    • Informs potential therapeutic strategies targeting insulin secretion in pediatric metabolic health.