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Anthelmintic activity of 13-alkoxy milbemycin derivatives
Yoko Sugiyama1, Makio Kobayashi, Akio Saito
1Medicinal Chemistry Research Lab. and Intellectual Property Department Sankyo Co., Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan.
The Journal of Antibiotics
|July 23, 2003
Abstract:
A number of 13-alkoxy milbemycin derivatives were synthesized to evaluate their anthelmintic activity. We report the strategy for developing a potent anthelmintic product, 13-[4-(N-methanesulfonyl-N-methylamino)-phenylethyloxy]milbemycin. The details of the structure-activity relationships of those derivatives are also discussed.