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Septic cavernous sinus thrombophlebitis: a review of 35 cases
Journal of the Indian Medical Association
|November 1, 1992
Abstract:
Thirty-five cases of septic cavernous sinus thrombophlebitis seen over the past 5 years are reviewed. Of these 80% were secondary to infection of the medial 1/3rd of the face. In more than 2/3rds of the cases the infecting organism was Staphylococcus aureus. Even with appropriate antibiotic therapy the overall mortality was 34.3%.
Insights
Septic cavernous sinus thrombophlebitis, often stemming from facial infections, carries a high mortality rate of over 34% despite antibiotic treatment. Staphylococcus aureus is the most common pathogen identified.
Area of Science:
- Otolaryngology
- Neurology
- Infectious Diseases
Background:
- Septic cavernous sinus thrombophlebitis (CST) is a rare but life-threatening condition.
- Facial infections are a common preceding cause of CST.
- Staphylococcus aureus is frequently implicated in CST pathogenesis.
Purpose of the Study:
- To review cases of septic cavernous sinus thrombophlebitis.
- To identify common causes and causative organisms.
- To assess treatment outcomes and mortality rates.
Main Methods:
- Retrospective review of 35 cases of septic cavernous sinus thrombophlebitis.
- Analysis of patient data over a 5-year period.
- Evaluation of infection sources, microbial agents, and treatment responses.
Main Results:
- 80% of cases originated from infections in the medial third of the face.
- Staphylococcus aureus was identified as the causative organism in over two-thirds of cases.
- The overall mortality rate remained high at 34.3% despite appropriate antibiotic therapy.
Conclusions:
- Facial infections, particularly in the medial third, are a significant risk factor for CST.
- Staphylococcus aureus is the predominant pathogen.
- Effective antibiotic therapy alone does not sufficiently reduce the high mortality associated with septic cavernous sinus thrombophlebitis.
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