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Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic
Rashmi Sareen1, Nitin Jain1, K L Dhar2
1a School of Pharmacy, Bharat Institute of Technology , Meerut , Uttar Pradesh , India and.
Pharmaceutical Development and Technology
|April 30, 2015
Summary
This study prepared a Curcumin-Zn(II) complex, enhancing curcumin
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Materials Science
Background:
- Curcumin, a natural compound, has limited solubility, stability, and therapeutic efficacy.
- Ulcerative colitis is a chronic inflammatory bowel disease with significant unmet medical needs.
Purpose of the Study:
- To synthesize and characterize a Curcumin-Zinc(II) complex.
- To evaluate the enhanced solubility, stability, and pharmacodynamic effects of the Curcumin-Zn(II) complex.
- To assess the efficacy of the Curcumin-Zn(II) complex in a mouse model of ulcerative colitis.
Main Methods:
- Curcumin-Zn(II) complex synthesized via stirring curcumin with anhydrous zinc chloride (1:1 molar ratio).
- Characterization using Thin-Layer Chromatography (TLC), Fourier-Transform Infrared (FTIR) spectroscopy, UV-Visible spectroscopy, and Proton Nuclear Magnetic Resonance ((1)H NMR).
- In vitro kinetic degradation and solubility studies, followed by in vivo pharmacodynamic evaluation in experimentally induced ulcerative colitis in mice.
Main Results:
- Successful chelation of curcumin with zinc ion confirmed by spectroscopic and analytical techniques (TLC, FTIR, UV, (1)H NMR).
- Curcumin-Zn(II) complex demonstrated significantly improved kinetic stability and solubility compared to free curcumin.
- In vivo studies showed a marked reduction in the severity and extent of colonic damage in mice treated with the Curcumin-Zn(II) complex, supported by histopathological findings.
Conclusions:
- The Curcumin-Zn(II) complex exhibits superior solubility and stability.
- The enhanced properties of the Curcumin-Zn(II) complex translate to improved pharmacodynamic effects, offering potential therapeutic benefits for ulcerative colitis.
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