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Thrombomodulin.

H Weiler1, B H Isermann

  • 1Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA. hweiler@bcsew.edu

Journal of Thrombosis and Haemostasis : JTH
|July 23, 2003
PubMed
Summary

Thrombomodulin (TM) is vital for blood clotting and has new roles in inflammation and development. Research explores its structure, function, and links to diseases like cancer and stroke.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Thrombomodulin (TM) is a key cofactor in the protein C anticoagulant pathway.
  • Emerging evidence highlights TM's roles beyond anticoagulation, including in fibrinolysis, inflammation, and embryogenesis.

Purpose of the Study:

  • To review recent structural and functional studies of TM.
  • To explore TM gene polymorphisms and their association with human diseases.
  • To detail TM's emerging functions in inflammation and embryogenesis.

Main Methods:

  • Biochemical and structural investigations.
  • In vivo analyses using genetically engineered mice.
  • Review of existing literature on TM gene polymorphisms and disease associations.

Main Results:

  • TM possesses critical functions independent of the protein C pathway.
  • TM plays significant roles in fibrinolysis, inflammation, and embryogenesis.
  • TM gene variations are linked to various human diseases, including thrombosis, stroke, arteriosclerosis, and cancer.

Conclusions:

  • Thrombomodulin is a multifunctional protein with implications in diverse physiological and pathological processes.
  • Further research into TM's structure-function relationship and disease associations is warranted.
  • TM's novel roles in inflammation and embryogenesis offer new therapeutic targets.

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