Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inherited platelet-based bleeding disorders.

M Cattaneo1

  • 1Unit of Hematology and Thrombosis, Ospedale San Paolo, Department of Medicine, Surgery and Dentistry, University of Milan, Milan, Italy. marco.cattaneo@unimi.it

Journal of Thrombosis and Haemostasis : JTH
|July 23, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026
Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026
Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026
Same author

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Physical review letters·2026
Same author

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

Physical review letters·2026
Same author

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Physical review letters·2026
Same journal

The Natural Mutation Arg221aTrp in Human α-Thrombin Abrogates Physiological Na<sup>+</sup> Binding and Preferentially Hinders the Protease Anticoagulant Functions.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

A historical review of the biological, semantic and clinical aspects of aspirin resistance.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Association between Thrombus Neutrophil Extracellular Traps Content and Ischemic Stroke Recurrence.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Peptide-Mediated Inhibition of Surface-Initiated Thrombogenesis.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Growth differentiation factor-15 and bleeding risk in patients with venous thromboembolism.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Physiological Anticoagulant Deficiencies: Pathogenesis, Diagnosis, and Clinical Implications.

Journal of thrombosis and haemostasis : JTH·2026
See all related articles

This review classifies inherited platelet disorders based on component abnormalities. It details inherited thrombocytopenias and hereditary platelet function disorders, discussing underlying defects.

Area of Science:

  • Hematology
  • Genetics
  • Molecular Biology

Background:

  • Inherited platelet disorders encompass abnormalities in platelet number and function.
  • Current classifications based on function are often unclear.
  • A revised classification based on shared component characteristics is proposed.

Purpose of the Study:

  • To review and classify inherited platelet-based bleeding disorders.
  • To discuss the underlying defects of these conditions.
  • To highlight the underdiagnosis of inherited thrombocytopenias.

Main Methods:

  • Literature review of inherited platelet disorders.
  • Classification based on platelet component abnormalities.
  • Discussion of underlying genetic and molecular defects.

Related Experiment Videos

Main Results:

  • Inherited thrombocytopenias are rare and likely underdiagnosed.
  • Hereditary platelet function disorders are categorized by defects in receptors, granules, signaling, phospholipids, or other functions.
  • The review provides a structured overview of these diverse conditions.

Conclusions:

  • A classification based on platelet component abnormalities offers a clearer approach to inherited platelet disorders.
  • Understanding these defects is crucial for diagnosis and management.
  • Further research is needed to address the underdiagnosis of inherited thrombocytopenias.