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Updated: Jun 29, 2026
07:05
Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy
Published on: September 27, 2024
Association between thrombus neutrophil extracellular trap content and ischemic stroke recurrence
Hyungwoo Lee1, JoonNyung Heo1, Jae Wook Jung1
1Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Journal of Thrombosis and Haemostasis : JTH
|June 27, 2026
Summary
High neutrophil extracellular traps (NETs) in stroke clots predict long-term recurrence. This finding suggests NETs burden indicates a thromboinflammatory state linked to recurrent ischemic events.
Area of Science:
- Neurology
- Immunology
- Cardiovascular Science
Background:
- Neutrophil extracellular traps (NETs) are key in immunothrombosis, linking inflammation and coagulation.
- NETs in retrieved thrombi correlate with poor short-term outcomes in ischemic stroke.
- Prognostic value of thrombus NETs for long-term stroke recurrence is unknown.
Purpose of the Study:
- To investigate the association between thrombus NETs content and stroke recurrence.
- To assess NETs burden in patients undergoing endovascular thrombectomy (EVT).
Main Methods:
- Retrospective analysis of a prospective registry study.
- Included patients with acute ischemic stroke treated with EVT and thrombus retrieval.
- Quantitative assessment of NETs content via immunohistochemistry.
Main Results:
- High NETs group (23.0% of 452 patients) had significantly higher recurrence rates (log-rank p = 0.013).
- High thrombus NETs content independently predicted stroke recurrence (HR, 2.24; 95% CI, 1.18-4.25; p = 0.014).
- Continuous NETs analysis showed a linear association with recurrence risk (p < 0.001).
Conclusions:
- Elevated NETs burden in thrombi is linked to increased long-term ischemic stroke recurrence risk.
- Thrombus NETs content may reflect an underlying thromboinflammatory phenotype.
- NETs may serve as a biomarker for predicting recurrent ischemic events.
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