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Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors
Hideki Moriyama1, Takahiro Tsukida, Yoshimasa Inoue
1Japan Bioindustry Association, Hokkaido Collaboration Center, N-21, W-12, Kita-Ku, Sapporo 001-0021, Japan.
Bioorganic & Medicinal Chemistry Letters
|July 23, 2003
Abstract:
In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.