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Published on: November 8, 2015
Successful treatment of anogenital lichen sclerosus with topical tacrolimus
Markus Böhm1, Uta Frieling, Thomas A Luger
1Department of Dermatology, University of Münster, Münster, Germany. bohmm@uni-muenster.de
Background:
Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice.
Observations:
Three prepubertal girls and 3 adults (2 men, 1 woman) were treated with 0.1% tacrolimus ointment once daily. All patients experienced complete resolution with long-lasting remission for up to 1 year. No major adverse effects were observed, and treatment was well tolerated.
Conclusions:
Topical tacrolimus is a promising novel agent in the treatment of lichen sclerosus of the anogenital area. A major advantage over topical corticosteroids is the lack of skin atrophy. Further clinical trials are warranted to confirm our findings.
