Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteomics in alcohol research.

Helen Anni1, Yedy Israel

  • 1Department of Pathology, Anatomy, and Cell Biology, Alcohol Research Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Alcohol Research & Health : the Journal of the National Institute on Alcohol Abuse and Alcoholism
|July 24, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut Microbiota-Derived Extracellular Vesicles Influence Alcohol Intake Preferences in Rats.

Journal of extracellular vesicles·2025
Same author

Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats.

Scientific reports·2024
Same author

Morphine self-administration is inhibited by the antioxidant N-acetylcysteine and the anti-inflammatory ibudilast; an effect enhanced by their co-administration.

PloS one·2024
Same author

Chronic Voluntary Morphine Intake Is Associated with Changes in Brain Structures Involved in Drug Dependence in a Rat Model of Polydrug Use.

International journal of molecular sciences·2023
Same author

Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell-derived secretome in preclinical models of morphine dependence.

CNS neuroscience & therapeutics·2023
Same author

Role of Metabolism on Alcohol Preference, Addiction, and Treatment.

Current topics in behavioral neurosciences·2023

Proteomics studies the complete set of proteins (proteome) in an organism. This research uses advanced techniques to understand how alcohol impacts protein networks, aiding alcoholism diagnosis and treatment discovery.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Proteomics

Background:

  • The proteome, an organism's complete set of proteins, is more complex than its genome.
  • Proteomics investigates proteome changes under various conditions, including alcohol exposure.
  • Alcohol significantly alters proteins across different cell types.

Purpose of the Study:

  • To map large proteomes, such as the human proteome.
  • To understand alcohol's global influence on protein structure, function, interactions, and networks.
  • To aid in early alcoholism diagnosis, prognosis, and the development of new therapeutic targets.

Main Methods:

  • High-resolution two-dimensional electrophoresis and multidimensional liquid chromatography for protein separation.
  • Mass spectrometry for individual protein identification.

Related Experiment Videos

  • Bioinformatics tools and high-speed computers for analyzing large datasets.

    • Main Results:

    • Detailed mapping of complex proteomes.
    • Identification of alcohol-induced alterations in protein structure and function.
    • Elucidation of changes in protein-protein interactions and networks due to alcohol.

    Conclusions:

    • Proteomic analysis provides critical insights into alcohol's molecular effects.
    • This knowledge can lead to improved diagnostic and prognostic tools for alcoholism.
    • Findings support the discovery of novel drug targets and medications for alcohol-related disorders.