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Updated: Sep 21, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Roles of interleukin-10 in acute graft-versus-host disease and graft rejection
Xiaoping Ju1, Jianmin Wang, Bin Xu
1Department of Hematology, Changhai Hospital, Shanghai 200433, China. xubin@smmu.edu.cn
Objective:
To study the role of interleukin (IL)-10 in acute-graft-versus-host disease (aGVHD) and graft rejection.
Methods:
Serum concentrations of IL-10 in 28 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) were measured by enzymed-linked immunosorbent assay (ELISA). IL-10 gene expression in peripheral mononuclear cells was measured by reverse-transcriptase polymerase chain reaction (RT-PCR) after transplantation.
Results:
Seven patients developed grade I GVHD, 7 patients developed grade II-IV GVHD, 4 patients had graft rejection. Before transplantation, the concentrations of IL-10 were higher in patients who later did not developed aGVHD. After transplantation, IL-10 levels increased in patients without aGVHD, but decreased in patients with aGVHD or graft rejection. And IL-10mRNA was more frequent in patients without aGVHD compared to those with aGVHD.
Conclusions:
IL-10 plays a negative role in the development of aGVHD and graft rejection.
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