Botulinum neurotoxin type B--a rapid wrinkle reducer

Botulinum toxin has been used for temporary muscle paralysis for over 13 years. The off label use of neurotoxins include treatment of dynamic lines on the face and treatment of hyperhidrosis. Several forms of botulinum toxin exist, but only 2 serotypes are available commercially. Botulinum toxin B (BoTX B) is a recently US Food and Drug Administration (FDA) approved neurotoxin used for the treatment of cervical dystonia. Investigations into the use of BoTX B for skin rejuvenation have shown rapid paralysis and reduction of wrinkles. This overview highlights the current reports on the efficacy, duration, and safety of BoTX B when used for cosmetic procedures.