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Related Experiment Videos

Racial differences in mammographic breast density.

Marcela G del Carmen1, Kevin S Hughes, Elkan Halpern

  • 1Vincent Memorial Gynecologic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

Cancer
|July 25, 2003
PubMed
Summary
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African American women have lower mammographic breast density than Caucasian and Latina women. This finding may impact breast cancer screening efficacy and requires further investigation into other contributing factors.

Area of Science:

  • Radiology and Medical Imaging
  • Oncology
  • Public Health

Background:

  • African American women exhibit lower breast carcinoma incidence but higher mortality rates compared to Caucasian women.
  • Decreased screening efficacy in African American women is a potential explanation for this disparity.
  • Higher breast density in African American women could reduce mammography sensitivity.

Purpose of the Study:

  • To investigate potential differences in mammographic breast density between African American and Caucasian women.
  • To determine if race is an independent factor influencing mammographic breast density.

Main Methods:

  • A cohort of 769 women was analyzed across five study sites.
  • Mammograms were centrally reviewed by seven readers using Breast Imaging Reporting and Data System (BI-RADS) numerical values.

Related Experiment Videos

  • Analysis of covariance (ANCOVA) compared mean mammographic densities across racial groups, adjusting for reader, age, and body mass index (BMI).

    • Main Results:

    • African American women demonstrated the lowest mean breast density (2.43), followed by Latina (2.65) and Caucasian (2.69) women.
    • An independent racial effect on breast density was observed even after adjusting for age, BMI, and reader (P = 0.0050).

    Conclusions:

    • Mammographic breast density is significantly lower in African American women compared to Caucasian and Latina women.
    • This racial difference in breast density may be intrinsic and warrants further research into undetermined causes.
    • Future studies should explore tumor growth rates and calcification incidence to fully assess impacts on mammography screening efficacy for African American women.