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The immune response of sheep to subclinical chronic exposure to the herbicide Bentazon TP
1Department of Microbiology and Immunology, University of Veterinary Medicine, Kosice, Czechoslovakia.
Veterinary and Human Toxicology
|December 1, 1992
Abstract:
A study of the effect of the Czechoslovakian herbicide BENTAZON TP on cells of the sheep immune system was carried out over a 3-mo period. A temporary decline in the number of T-lymphocytes in the peripheral blood was seen after 6 w of daily feeding of the herbicide. Dose-dependent statistically significant changes in the leucocyte migration index (p < 0.05) were seen at daily doses of 1/10 the LD50 (195 mg/kg body weight) and 1/20 the LD50 (97.5 mg/kg body weight) the 8th and 10th w of feeding, respectively. Significant changes of phagocytic activity and in the phagocytic index were not observed.