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Metal-enhanced emission from indocyanine green: a new approach to in vivo imaging
Joanna Malicka1, Ignacy Gryczynski, Chris D Geddes
1University of Maryland School of Medicine, Department of Biochemistry & Molecular Biology, Center for Fluorescence Spectroscopy, 725 W. Lombard Street, Baltimore, Maryland 21201-1503, USA.
Abstract:
Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.
