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[Interferon alpha-2b inhibits rabbit corneal haze induced by PRK]
Ming-Chang Zhang1, Bin Li, Yan-Hua Hu
1Department of Ophthalmology, Union Hospital Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430022, China. mingchangzhang488@hotmail.com
Objectives:
To evaluate the effect of interferon alpha-2b on the treatment of corneal haze after PRK.
Methods:
36 rabbits were divided into three groups (A.B.C). The refractive degree of ablation was -4.00 D, -8.00 D, -10.00 D in each group respectively. The treatment given in group A was 1 x 10(5) IU/ml interferon alpha-2b, in group B 0.1% dexamethasone and placebo eyedrops for group C after PRK 2 months. Corneal haze, histopathologic response, intraocular pressure (IOP) were investigated.
Results:
Less corneal haze was observed in group A and B. Postoperative IOP was higher than that of preoperation in group B. Keratocytes and fibrotic response in corneal stroma were active up to 2 months in group C.
Conclusions:
Interferon alpha-2b was effective on inhibition of corneal haze after PRK.