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Updated: Sep 30, 2026
Real-time Digital Imaging of Leukocyte-endothelial Interaction in Ischemia-reperfusion Injury (IRI) of the Rat Cremaster Muscle
Published on: August 5, 2012
Distribution pattern of capillary and venular red blood cell velocity following ischemia-reperfusion in striated
M D Menger1, G Feifel, K Messmer
1Institute for Surgical Research, University of Munich, FRG.
Abstract:
Ischemia-reperfusion induced changes in distribution pattern of RBC-velocity of nutritive capillaries and postcapillary venules was analyzed in striated muscle using intravital fluorescence microscopy in awake hamsters. Four hours of ischemia to striated muscle contained in the dorsal skinfold preparation (n = 10) revealed a significant (p < 0.01) decrease of capillary, but only a slight decrease of mean venular RBC-velocity during the entire reperfusion period. However, analysis of distribution pattern of single values revealed a shift of the histograms to the left, including pronounced skewness as mean values approached zero. This characteristic phenomenon may be due to an increase of microvascular hematocrit and/or decrease in deformability of red blood cells during ischemia-reperfusion. Beside other factors, the impairment of flow properties and flow conditions of the blood may contribute to the development of microvascular reperfusion injury.
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