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Oxidative stress and aging: beyond correlation.

Tamara R Golden1, Douglas A Hinerfeld, Simon Melov

  • 1Buck Institute for Age Research, Novato, CA 94945, USA.

Aging Cell
|July 29, 2003
PubMed
Summary
This summary is machine-generated.

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The oxidative stress theory of aging suggests reactive oxygen species contribute to aging. Studies in invertebrates and mammals indicate oxidative damage limits lifespan and causes age-related dysfunction.

Area of Science:

  • Gerontology
  • Cellular Biology
  • Biochemistry

Background:

  • The oxidative stress theory of aging is supported by circumstantial evidence.
  • Mitochondrially generated reactive oxygen species (ROS) are implicated in organismal aging.
  • Direct testing of the ROS hypothesis in model systems is ongoing.

Purpose of the Study:

  • To review the evidence supporting the role of oxidative stress in aging.
  • To examine the impact of mitochondrially generated ROS on lifespan and age-related dysfunction.
  • To assess findings in both invertebrate and mammalian model systems.

Main Methods:

  • Review of existing literature on oxidative stress and aging.
  • Analysis of studies testing the ROS hypothesis in model organisms.

Related Experiment Videos

  • Examination of data from invertebrate models (Drosophila melanogaster, Caenorhabditis elegans) and mammalian models.

    • Main Results:

    • Initial results in invertebrates suggest superoxide levels limit lifespan.
    • Evidence indicates oxidative damage plays a role in invertebrate aging.
    • In mammals, the effect of oxidative stress on lifespan is less clear, but antioxidant treatment shows protective effects against age-related dysfunction, including cognitive decline.

    Conclusions:

    • Oxidative stress, particularly from superoxide, appears to limit lifespan in invertebrates.
    • Antioxidant interventions show promise in mitigating age-related dysfunction in mammals.
    • Further research is needed to fully elucidate the role of oxidative stress in mammalian aging.