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Liver transplantation in neonates.
Shikha S Sundaram1, Estella M Alonso, Peter F Whitington
1Siragusa Transplantation Center, Children's Memorial Hospital, The Feinberg School of Medicine of Northwestern University, Chicago, IL 60614, USA.
Summary
Neonatal orthotopic liver transplantation (OLT) is a recent advancement for end-stage liver disease in newborns. This overview examines the current data and experiences with this complex pediatric procedure.
Area of Science:
- Pediatric Surgery
- Hepatology
- Transplantation Medicine
Background:
- Orthotopic liver transplantation (OLT) is the standard for pediatric end-stage liver disease.
- Technical advancements enable OLT in younger, smaller patients, including infants.
- Neonatal OLT is a recent frontier with limited data.
Purpose of the Study:
- To provide an overview of neonatal OLT.
- To review current data and center experiences in neonatal liver transplantation.
- To discuss the evolution and extension of OLT into the neonatal population.
Main Methods:
- Review of existing literature on neonatal OLT.
- Analysis of data from major pediatric transplant centers.
- Synthesis of institutional experience in neonatal liver transplantation.
Main Results:
- OLT is now routinely performed in infants with high survival rates.
- Neonatal OLT shows promising survival success in limited reports.
- A growing cohort of school-aged children are recipients of infant OLT.
Conclusions:
- Neonatal OLT represents a significant advancement in pediatric transplantation.
- Further research and data collection are crucial for this emerging field.
- Successful OLT in neonates offers hope for the youngest patients with liver failure.