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Equilibrium water sorption in human stratum corneum
Gerald B Kasting1, Namrata D Barai
1College of Pharmacy, The University of Cincinnati, PO Box 670004, Cincinnati, Ohio 45267-0004, USA. Gerald.Kasting@uc.edu
Journal of Pharmaceutical Sciences
|July 29, 2003
Summary
Skin
Area of Science:
- Dermatology and Biophysics
- Materials Science
Background:
- Stratum corneum (SC) water content is crucial for skin barrier function and permeability.
- Understanding SC water sorption is key to managing skin hydration and health.
Purpose of the Study:
- To characterize the equilibrium water sorption isotherm of human SC.
- To fit theoretical water sorption models to experimental SC data.
Main Methods:
- Analysis of water uptake in excised human SC.
- Fitting Brunauer-Emmett-Teller (BET), D'Arcy-Watt, and Frenkel-Halsey-Hill models to SC water sorption data.
Main Results:
- Human SC water sorption shows similarities to keratinized tissues at low activity and hydrogels at high activity.
- BET, D'Arcy-Watt, and Frenkel-Halsey-Hill models accurately describe SC water content across a wide water activity range (0.03-1.0).
Conclusions:
- Theoretical models effectively characterize human SC water sorption.
- SC water content significantly influences skin barrier homeostasis and permeability.