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Related Experiment Videos

Methotrexate in recurrent postpericardiotomy syndrome.

Nili Zucker1, Aviva Levitas, Eli Zalzstein

  • 1Pediatric Cardiology Unit, Division of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel. niliz@bgumail.bgu.ac.il

Cardiology in the Young
|July 31, 2003
PubMed
Summary

Chronic postpericardiotomy syndrome is rare but can be successfully treated with low-dose methotrexate, offering an alternative to steroids for recurrent pericardial effusions in children.

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Area of Science:

  • Cardiology
  • Pediatric Surgery
  • Rheumatology

Background:

  • Postpericardiotomy syndrome (PPS) affects up to one-third of children post-cardiac surgery.
  • Standard PPS treatments include anti-inflammatory drugs, diuretics, and effusion drainage.
  • Steroids offer benefits but carry significant adverse effects.

Observation:

  • A rare case of chronic PPS with persistent, recurrent pericardial effusions and steroid dependency is presented.
  • The patient required ongoing steroid treatment due to the chronic nature of the syndrome.

Findings:

  • Successful treatment of chronic PPS was achieved using a low weekly dose of methotrexate.
  • Methotrexate provided an effective alternative to prolonged steroid use.

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Implications:

  • Low-dose methotrexate may be a viable therapeutic option for managing chronic, refractory postpericardiotomy syndrome in pediatric patients.
  • This approach could mitigate the risks associated with long-term steroid therapy.
  • Further research into methotrexate for chronic PPS is warranted.