Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular development and patterning: making the right choices.

Janet Rossant1, Masanori Hirashima

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada. rossant@mshri.on.ca

Current Opinion in Genetics & Development
|July 31, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human stem cell-based embryo models: innovation, ethics, and policy.

Human reproduction (Oxford, England)·2026
Same author

Enhancing rigor and reproducibility: Implementing STAR Methods and the ISSCR Standards Checklist at Stem Cell Reports.

Stem cell reports·2026
Same author

Lysophosphatidic acid-mediated NF-κB activation promotes FOXC2 expression essential for lymphatic valve development.

The Journal of clinical investigation·2026
Same author

Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited.

Stem cell reports·2025
Same author

Author Correction: A comprehensive human embryo reference tool using single-cell RNA-sequencing data.

Nature methods·2025
Same author

Editorial.

Stem cell reports·2025
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Vascular development relies on signaling molecules like VEGFs and angiopoietins to specify blood and lymphatic vessel cell identity. Notch signaling differentiates arteries and veins, while VEGF-C/D and Prox1 define lymphatic vessels.

Area of Science:

  • Developmental Biology
  • Vascular Biology
  • Cell Signaling

Background:

  • The vascular system's formation and specialization involve complex signaling pathways.
  • Endothelial cell identity is established early in embryonic development.
  • Vessels are specialized for blood circulation (arterial/venous) or lymph transport (lymphatic).

Purpose of the Study:

  • To elucidate the signaling mechanisms regulating vascular system development.
  • To understand how endothelial cell identity dictates vessel specialization.
  • To identify key molecular players in arterial, venous, and lymphatic fate determination.

Main Methods:

  • Review of genetic studies in model organisms (zebrafish, mice).
  • Analysis of signaling pathways including VEGFs, angiopoietins, and Notch.

Related Experiment Videos

  • Investigation of transcription factor roles, such as Prox1.

    • Main Results:

    • Vascular Epithelial Growth Factors (VEGFs) and angiopoietins are crucial for endothelial cell identity.
    • Notch signaling, downstream of VEGF-A, is critical for specifying arterial versus venous fates.
    • VEGF-C, VEGF-D, and the transcription factor Prox1 are key for lymphatic vessel specification.

    Conclusions:

    • Specific signaling pathways and transcription factors orchestrate vascular development.
    • Distinct molecular cues determine whether a vessel becomes arterial, venous, or lymphatic.
    • Understanding these pathways is fundamental to vascular biology and regenerative medicine.