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Updated: Sep 20, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis
Published on: March 14, 2018
An uncertainty principle in chromosome positioning
Luis A Parada1, Jeffrey J Roix, Tom Misteli
1National Cancer Institute, Bethesda, MD 20892, USA.
Abstract:
Chromosomes are non-randomly positioned in the mammalian interphase nucleus. It is not known how patterns of chromosome positions are established or to what degree spatial arrangements of chromosomes change during the cell cycle, especially during mitosis. Two reports have applied in vivo microscopy to track chromosomes in space and time. The results highlight the inherently imperfect and probabilistic nature of chromosome positioning in the cell nucleus.
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