An uncertainty principle in chromosome positioning

Luis A Parada1, Jeffrey J Roix, Tom Misteli

  • 1National Cancer Institute, Bethesda, MD 20892, USA.

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Forces Acting on Chromosomes02:11

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During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis. 
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