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Anabaptist genealogy database.

Richa Agarwala1, Leslie G Biesecker, Alejandro A Schäffer

  • 1National Center for Biotechnology Information/NIH, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
|July 31, 2003
PubMed
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The Anabaptist Genealogy Database (AGDB) aids geneticists in mapping disease genes by providing a secure, searchable genealogy. This resource supports genetic research while protecting individual privacy.

Area of Science:

  • * Genetics
  • * Bioinformatics
  • * Genealogy

Background:

  • * Established in 1996 to create a computer-searchable genealogy of Old Order Amish in Lancaster County, Pennsylvania.
  • * Expanded to include broader Anabaptist populations and individuals outside Lancaster County, leading to the renaming as the Anabaptist Genealogy Database (AGDB).

Purpose of the Study:

  • * To expedite gene mapping for rare recessive disorders studied at the National Institutes of Health (NIH).
  • * To develop and provide the PedHunter software for genetic database queries.
  • * To offer genealogy assistance to external researchers while ensuring data confidentiality.

Main Methods:

  • * Construction of a comprehensive, computer-searchable genealogical database.
  • * Integration of complementary data sources to broaden population coverage.

Related Experiment Videos

  • * Development of the PedHunter software for querying genetic and genealogical data.

    • Main Results:

    • * Successful creation and implementation of the Anabaptist Genealogy Database (AGDB).
    • * Accomplishment of all initial project goals, including gene mapping support and software development.
    • * Over 100 queries answered for external researchers over five years, demonstrating significant utility.

    Conclusions:

    • * The Anabaptist Genealogy Database (AGDB) has successfully supported genetic research and data sharing.
    • * The project highlights the value of specialized genealogical databases in biomedical research.
    • * Future projects can leverage AGDB for further genetic studies and population research.