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Facile synthesis of an azido-labeled thalidomide analogue
Scott M Capitosti1, Todd P Hansen, Milton L Brown
1Department of Chemistry, University of Virginia, P.O. Box 400319, Charlottesville, Virginia 22904, USA.
Organic Letters
|August 2, 2003
Abstract:
[reaction: see text] A five-step synthesis of an azido-thalidomide analogue is presented. The sequence requires cheap and readily available starting materials and reagents, and only two steps require purification. Additionally, the azido-labeled analogue possesses activity comparable to that of thalidomide in inhibiting the proliferation of human microvascular endothelial cells, thus providing impetus for its use as a potential photoaffinity label of thalidomide.