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Touch and go: tying TonB to transport
Kathleen Postle1, Robert J Kadner
1School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234, USA.
Molecular Microbiology
|August 2, 2003
Summary
The TonB system in Gram-negative bacteria energizes outer membrane transport. This review updates recent developments in understanding this crucial energy transduction system.
Area of Science:
- Microbiology
- Molecular Biology
- Biochemistry
Background:
- The TonB system is essential for Gram-negative bacteria.
- It links energy from the cytoplasmic membrane to the outer membrane.
Purpose of the Study:
- To review recent advancements in TonB system research.
- To update the understanding of energy transduction in bacterial outer membranes.
Main Methods:
- Literature review of studies published since 1990.
- Synthesis of current knowledge on TonB system function.
Main Results:
- The TonB system transduces proton motive force energy.
- This energy powers the uptake of nutrients like iron siderophores and vitamin B12.
- Pathogens utilize TonB for iron acquisition from hosts.
Conclusions:
- The TonB system remains a vital component of Gram-negative bacterial physiology.
- Ongoing research continues to elucidate its complex mechanisms and roles.