Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variable manifestation in natural killer cell leukaemia.

J Kuroda1, S Kimura, Y Kobayashi

  • 1Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.

Clinical and Laboratory Haematology
|August 2, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

5-HT3 receptor antagonists. 1. New quinoline derivatives.

Journal of medicinal chemistry·1992
Same author

New bronchodilators. II. 3H-imidazo[4,5-c]quinolin-4(5H)-ones.

Chemical & pharmaceutical bulletin·1992
Same author

Site of attachment of mercuribenzoate in crystals of an actin:DNase I complex.

Journal of biochemistry·1992
Same author

Further studies on aspartate aminotransferase of thermophilic methanogens by analysis of general properties, bound cofactors, and subunit structures.

Journal of biochemistry·1992
Same author

Elevated expression of the ornithine decarboxylase gene in human esophageal cancer.

Cancer research·1992
Same author

Experimental chemotherapy for xenograft cell lines of human bile duct and gall bladder cancers in nude mice.

Journal of surgical oncology·1992

Natural killer (NK) cell leukaemias are rare hematologic disorders that can be challenging to diagnose. Comprehensive individual studies are crucial for accurate diagnosis and optimal treatment of these T/NK lymphoproliferative disorders.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Natural killer (NK) cell leukaemias, now classified under T/NK lymphoproliferative disorders, are rare hematologic malignancies.
  • Diagnosis and subtyping can be challenging due to the absence of distinct diagnostic hallmarks, particularly at initial presentation.

Purpose of the Study:

  • To describe the clinical, cytological, immunological, and cytogenetic characteristics of five patients with NK leukaemias.
  • To highlight diagnostic and therapeutic challenges in NK cell leukaemias.

Main Methods:

  • Case series describing five patients with NK leukaemias.
  • Analysis of clinical presentation, morphology, immunophenotype, and cytogenetics.
  • Review of treatment responses and outcomes.

Related Experiment Videos

Main Results:

  • Varied clinical and cytological presentations were observed, including hypogranular variants of aggressive NK cell leukaemia/lymphoma (ANKL/L) and haemophagocytic syndrome.
  • Systemic chemotherapy achieved complete remission in some ANKL/L and blastic NK cell leukaemia/lymphoma (BNKL/L) patients.
  • Allogeneic bone marrow transplantation led to a good long-term outcome in one CD4-positive BNKL/L patient. Recurrent chromosomal aberrations were rare, with two cases showing 10p11 and 11q13 abnormalities.

Conclusions:

  • Comprehensive individual patient studies are essential for accurate diagnosis of NK leukaemias.
  • Tailored therapeutic strategies are necessary for optimal management and improved outcomes in these rare leukaemias.