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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Survival rates are similar between African American and white patients with heart failure
Stephanie H Dunlap1, Sirisha Mallemala, Carla A Sueta
1Department of Medicine, School of Medicine, University of Illinois at Chicago, Chicago, Ill, USA.
Insights
Race does not impact heart failure survival. This study found similar survival rates for African American and white patients with symptomatic heart failure, regardless of disease cause or adjusted factors.
Area of Science:
- Cardiology
- Health Disparities
- Clinical Research
Background:
- Heart failure clinical characteristics differ between African American and white patients, potentially due to underlying pathobiology.
- Previous research suggests race may influence heart failure outcomes.
- This study investigates the impact of race on heart failure patient survival.
Purpose of the Study:
- To test the hypothesis that race influences survival in patients with heart failure.
- To compare survival rates between African American and white patients diagnosed with heart failure.
Main Methods:
- Analysis of data from 853 patients with symptomatic heart failure and reduced ejection fraction.
- Inclusion of patients from the University of North Carolina Heart Failure Database.
- Vital status data collected over a mean follow-up of 3.8 years.
Main Results:
- Unadjusted analysis showed no significant difference in survival rates between African American and white patients.
- Adjusted analysis, accounting for prognostic factors, also revealed no difference in survival.
- Specific analysis for heart failure due to ischemic heart disease showed no significant racial disparity in mortality.
Conclusions:
- African American and white patients with symptomatic heart failure exhibit similar survival rates.
- Race does not appear to be an independent predictor of survival in this heart failure cohort.
- Findings suggest that other factors may be more critical in determining heart failure prognosis across racial groups.
Background:
The clinical characteristics of heart failure differ significantly between African American patients and white patients, apparently as a result of differences in the pathobiology of the condition in the races. We investigated the hypothesis that race also influences the survival of patients with heart failure.
Methods:
Data from the University of North Carolina Heart Failure Database were analyzed for 853 patients (44% African American, 32% women) who had symptomatic heart failure (New York Heart Association class 2.8 +/- 0.02 [mean +/- SEM]) with a reduced left ventricular ejection fraction of 26% +/- 0.5% and a body mass index of 27 +/- 0.2. Data on vital status were available in 96.4% of these patients, with a mean length of follow-up of 3.8 +/- 0.1 years.
Results:
An unadjusted univariate proportional-hazards analysis suggested similar survival rates between African American patients and white patients in the study population (relative risk, 0.90; 95% CI, 0.73-1.10; P =.293). Adjusted analysis, taking into account the characteristics shown to be of prognostic importance, demonstrated no difference in survival rate between African American patients and white patients (relative risk,1.12; 95% CI, 0.89-1.42; P =.336). The adjusted relative risk of all-cause mortality in the respective races among patients with heart failure caused by ischemic heart disease was 1.21 (95% CI, 0.80-1.84; P =.367).
Conclusion:
African American and white patients with symptomatic heart failure had similar survival rates in our database.
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