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[Hereditary factors and left ventricular hypertrophy]

V A Brazhnik, D A Zateĭshchikov, B A Sidorenko

    Kardiologiia
    |August 2, 2003
    PubMed

    Insights

    Left ventricular hypertrophy (LVH) is a significant cardiovascular risk factor. Genetic factors, including genes in hormonal and receptor pathways, play a crucial role in its development.

    Area of Science:

    • Cardiology
    • Genetics
    • Molecular Biology

    Context:

    • Left ventricular hypertrophy (LVH) is a major independent risk factor for cardiovascular morbidity and mortality.
    • LVH is a stronger coronary risk factor in hypertensive patients than casual blood pressure readings.
    • The correlation between hypertension severity, duration, and left ventricular mass is often poor, suggesting other contributing factors.

    Purpose:

    • To review and present gene groups implicated in the development of left ventricular hypertrophy (LVH).
    • To identify specific genes associated with LVH development.
    • To explore the genetic underpinnings of LVH beyond traditional risk factors.

    Summary:

    • This review categorizes genes contributing to LVH development into five groups: hormonal pathways, sympathetic/parasympathetic receptors, intracellular ion homeostasis, energy metabolism, and motor unit regulation.
    • Specific genes identified and associated with LVH include those encoding angiotensinogen, angiotensin-converting enzyme, angiotensin receptor type 1, aldosterone synthase, nitric oxide synthase, type A natriuretic peptide receptor, beta(2)-adrenergic receptor, and G-protein beta(3) subunit.
    • These genetic factors offer potential targets for understanding and managing LVH.

    Impact:

    • Highlights the significant role of genetic predisposition in left ventricular hypertrophy.
    • Provides a framework for further research into gene-environment interactions in cardiovascular disease.
    • May inform future diagnostic and therapeutic strategies for managing LVH and its associated cardiovascular risks.

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