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Updated: Sep 20, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
[The multidrug resistance modulators heterocondensed quinazolones]
József Kökösi1, János Almási, Benjamin Podányi
1Semmelweis Egyetem, Gyógyszerészi Kémiai Intézet, Budapest, Hógyes E. u. 9.-1092.
Abstract:
Exploration for new MDR-modulators utilizing pyrazino[2,1-b]quinazolones as scaffolds disclosed after systematic synthetic investigation highly hydrophobic N-substituted derivatives as a readily accessible active tricyclic compounds. A versatile synthesis of 2-substituted-1,2,3,4-tetrahydro-6H-pyrazino[2,1-b]quinazoline-3,6-diones is presented starting from 2,3-substituted quinazolines. The new compounds have been characterized by elemental analyses, 1H nmr and in some cases by 13C ruler, and X-ray investigations.
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