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Updated: Mar 9, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
[Evidence-based medicine in 2025--what will remain?]
1Abteilung für Allgemeinmedizin, Rehabilitative und Präventive Medizin, Universität Marburg. norbert@med.uni-marburg.de
Evidence-based Medicine (EBM) has evolved, facing unmet expectations and conflicts. Despite challenges, EBM fostered a more scientific and self-critical clinical mentality among practitioners.
Area of Science:
- Medical Informatics
- Clinical Practice Guidelines
- Healthcare Policy
Context:
- The emergence of Evidence-based Medicine (EBM) in healthcare.
- Initial high expectations and subsequent challenges in EBM implementation.
- The role of vested interests and inherent conflicts within the healthcare system.
Purpose:
- To critically evaluate the long-term impact of Evidence-based Medicine (EBM).
- To discuss the fulfillment of initial expectations associated with EBM.
- To analyze EBM's influence on clinical practice and practitioner attitudes.
Summary:
- Evidence-based Medicine (EBM) has not fully met all initial expectations and has not eliminated healthcare controversies.
- Despite challenges, EBM has significantly shifted clinical mentality, promoting cooperation and self-criticism.
- Practitioners have adopted EBM as a critical tool for diagnosis, understanding causality, and guiding interventions.
Impact:
- EBM has fostered a more scientifically grounded and collaborative approach in healthcare.
- It has enhanced practitioners' critical appraisal skills for clinical decision-making.
- The long-term influence of EBM on medical practice and patient outcomes is a subject for ongoing evaluation.
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