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[Transient hyperphosphatasemia of infancy].

B Garty1, D Stayer, D Harell

  • 1Pediatrics Dept., Beilinson Medical Center, Petah Tikva.

Harefuah
|December 15, 1992
PubMed
Summary

Transient hyperphosphatasemia of infancy is a temporary condition in young children, marked by high alkaline phosphatase levels that normalize quickly. Recognizing this benign disorder avoids unnecessary medical tests and parental anxiety.

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Area of Science:

  • Pediatrics
  • Biochemistry
  • Clinical Medicine

Context:

  • Infancy and early childhood represent critical developmental periods.
  • Elevated serum alkaline phosphatase (SAP) can indicate various underlying pathologies.
  • Distinguishing benign conditions from serious diseases is crucial for appropriate patient management.

Purpose:

  • To describe the clinical and biochemical features of transient hyperphosphatasemia of infancy.
  • To highlight the diagnostic criteria and typical presentation of this benign condition.
  • To emphasize the importance of recognizing transient hyperphosphatasemia to prevent unnecessary investigations.

Summary:

  • Transient hyperphosphatasemia of infancy is characterized by a marked, temporary elevation in serum alkaline phosphatase (SAP) levels, often discovered during intercurrent infections in children under five.

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  • Key features include SAP levels 3-30 times the normal limit (originating from both liver and bone), rapid normalization within weeks, and absence of residual liver or bone disease.
  • This condition was observed in 4 hospitalized children over a 6-month period, representing 0.3% of admissions.

    • Impact:

    • Early recognition of transient hyperphosphatasemia prevents extensive and costly laboratory workups.
    • Accurate diagnosis alleviates unnecessary anxiety for parents and healthcare providers.
    • Understanding this benign condition improves diagnostic efficiency in pediatric care.