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Hydroxyurea-induced melanonychia concomitant with a dermatomyositis-like eruption
Shin Taek Oh1, Dong Won Lee, Jun Young Lee
1Department of Dermatology, St Mary's Hospital, The Catholic University of Korea, Seoul, Korea. hjlee@sph.cuk.ac.kr
Journal of the American Academy of Dermatology
|August 2, 2003
Summary
Hydroxyurea can cause melanonychia, a nail pigmentation. Some patients also developed a dermatomyositis-like skin rash alongside this side effect.
Area of Science:
- Dermatology
- Oncology
Background:
- Hydroxyurea is a medication used to treat myeloproliferative neoplasms and sickle cell disease.
- Melanonychia is a condition characterized by increased melanin in the nail unit.
Observation:
- This study reports on seven patients experiencing hydroxyurea-induced melanonychia.
- Two of these patients also presented with a dermatomyositis-like eruption.
Findings:
- Hydroxyurea is associated with the development of melanonychia.
- A subset of patients may exhibit concurrent dermatomyositis-like skin manifestations.
Implications:
- Clinicians should be aware of these potential dermatologic side effects of hydroxyurea.
- Monitoring patients for nail and skin changes during hydroxyurea therapy is recommended.