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RISK-ADAPTED MONITORING OF MELANOCYTIC LESIONS WITH PERIPHERAL GLOBULES: A LONGITUDINAL COHORT STUDY ON MELANOMA RISK
Kaan Gündüz1, Handan Merve Erol Mart2, Ömer Faruk Şimşek2
1Department of Dermatology, Ankara University School of Medicine, Ankara, Turkey; Department of Dermatology, Atılım University School of Medicine, Ankara, Turkey.
Journal of the American Academy of Dermatology
|August 6, 2026
Summary
Peripheral globules in melanocytic nevi are dynamic. Their persistence, increasing pigmentation, and faster growth predict adverse outcomes, aiding risk stratification beyond initial appearance.
Area of Science:
- Dermatology
- Dermoscopy
- Melanoma Research
Background:
- Peripheral globules in melanocytic nevi are typically seen as benign.
- Their long-term significance and predictive value for adverse outcomes are not well understood.
Purpose of the Study:
- To investigate if changes in peripheral globules over time predict adverse histopathologic outcomes.
- To assess the role of lesion dynamics in risk stratification.
Main Methods:
- A cohort of 1923 melanocytic lesions with peripheral globules was studied using sequential digital dermoscopy.
- Bayesian generalized linear mixed models analyzed longitudinal changes in globules, growth, and pigmentation.
Main Results:
- Nearly half (46.9%) of lesions showed globule resolution.
- Persistent or increasing globules, increasing pigmentation, and faster growth were linked to adverse histopathologic findings.
- A personal history of melanoma also increased risk.
Conclusions:
- Peripheral globules are dynamic features, not static indicators.
- Longitudinal analysis of melanocytic lesions, including peripheral globule behavior, enhances risk assessment beyond initial morphology.
