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Related Experiment Videos

Cutaneous ulceration caused by methotrexate.

Dana W Kazlow1, David Federgrun, Stephen Kurtin

  • 1Department of Dermatology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.

Journal of the American Academy of Dermatology
|August 2, 2003
PubMed
Summary
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Methotrexate therapy can cause skin ulceration in some psoriasis patients. This case shows ulcers healing after stopping methotrexate, but recurring upon reintroduction.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Psoriasis is a chronic autoimmune skin condition.
  • Methotrexate is a common immunosuppressive drug used to treat psoriasis.

Observation:

  • A 58-year-old male patient with plaque psoriasis developed ulcers.
  • Ulcers appeared on elbows, lower lip mucosa, and an appendectomy scar during methotrexate treatment.

Findings:

  • Methotrexate-induced skin ulceration occurred in psoriatic plaques and scars.
  • Ulcers resolved after discontinuing methotrexate.
  • Scar erosion recurred upon methotrexate reintroduction.

Implications:

  • Methotrexate requires careful monitoring for potential cutaneous side effects.

Related Experiment Videos

  • Understanding drug-induced ulceration is crucial for patient management.
  • This case highlights the importance of considering medication side effects in treatment decisions.