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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Acne Infection01:27

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Advanced Topical Nonsteroidal Therapies for Atopic Dermatitis: Consensus Statements from an Expert Panel.

April W Armstrong, Yvonne Nong, Christopher G Bunick

    Journal of Drugs in Dermatology : JDD
    |March 11, 2026
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    This summary is machine-generated.

    Advanced topical nonsteroidal therapies offer effective, safe options for atopic dermatitis (AD) management. These treatments provide sustained disease control and improve quality of life, reducing reliance on corticosteroids.

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    Area of Science:

    • Dermatology
    • Pharmacology
    • Inflammatory Diseases

    Background:

    • Topical nonsteroidal therapies offer targeted anti-inflammatory control for atopic dermatitis (AD).
    • Growing availability necessitates guidance on their use in AD management, including first-line therapy, maintenance, and combination regimens.

    Purpose of the Study:

    • To establish expert consensus on the clinical role of advanced topical nonsteroidal therapies in atopic dermatitis (AD).

    Main Methods:

    • A seven-dermatologist expert panel utilized a structured Delphi process and literature review.
    • Statements were developed, refined, and voted on across multiple rounds.
    • Evidence quality and recommendation strength were assessed using the Strength of Recommendation Taxonomy (SORT).

    Main Results:

    • Unanimous consensus was reached on seven advanced topical nonsteroidal therapies (e.g., ruxolitinib, tapinarof, roflumilast).
    • These therapies effectively reduce AD signs, symptoms (including pruritus), and are suitable as first-line agents.
    • Benefits include longer disease control, fewer relapses, reduced corticosteroid exposure, improved patient-reported outcomes, and favorable safety profiles without lab monitoring.

    Conclusions:

    • Advanced topical nonsteroidal therapies represent a significant advancement in atopic dermatitis (AD) management.
    • They are appropriate first-line options for various AD severities, promoting sustained disease control and enhancing quality of life.