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Updated: Jul 7, 2026

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
Published on: July 27, 2022
The emerging role of lysophosphatidic acid in cancer
Gordon B Mills1, Wouter H Moolenaar
1MD Anderson Cancer Center, Houston, Texas 77030, USA. gmills@mdanderson.org
Abstract:
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.
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