Early amidation approach to 3-[(4-amido)pyrrol-2-yl]-2-indolinones

Jerad M Manley¹, Monica J Kalman, Brian G Conway

¹Chemical Research and Development, Pfizer Inc, 0200-1500-91-201, 7000 Portage Road, Kalamazoo, Michigan 49001, USA.

|August 5, 2003

Abstract:

A new synthesis of 3-[(4-amido)pyrrol-2-yl]-2-indolinones has been developed, where the amide side chain was installed prior to pyrrole formation. This strategy precludes the need to use any coupling reagents to install the amide side chain. This process includes a zinc-free alternative to the Knorr pyrrole synthesis.

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Abstract:

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