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[Overexpression of COX-2 and its clinical significance in non-small cell lung cancer]
Feng Tian1, Tian-you Wang, Min Gong
1Department of Thoracic Surgery, Beijing Friendship Hospital, Capital University of Medical Science, Beijing 100050, China.
Objective:
To study the relations among COX-2 expression in non-small cell lung cancer (NSCLC), its clinical characteristics and brognosis.
Methods:
Immunostaining was performed with COX-2 antibody to the surgically resected tissue samples from 79 patients with NSCLC. Vessel epithelium cell COX-2 expression was taken as positive control.
Results:
The positive rate of adenocarcinoma and squamous cell carcinoma was 85% and 57%, respectively (P = 0.013). COX-2 expression was associated with the extent of adenocarcinoma differentiation, tumor size, and TNM period, but not with the extent of squamous cell carcinoma differentiation. In the COX-2 positive group, the 5-year survival rate and a median survival time were 27.1% and 53 months; however in the negative group they were 52.0% and 61 months (P = 0.029).
Conclusion:
Invasive development of NSCLC is related to inceased expression of COX-2. COX-2 overexpression may be one of the risky factors for the prognosis of NSCLC.
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