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[Clinical studies on cefprozil granules].

T Haruta1, T Tsutsui, S Kuroki

  • 1Department of Pediatrics, Kobe City General Hospital.

The Japanese Journal of Antibiotics
|December 1, 1992
PubMed
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Cefprozil granules demonstrated 100% clinical efficacy in pediatric bacterial infections, with no observed side effects. This study highlights its potential as a well-tolerated treatment option for children.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Bacteriology

Background:

  • Bacterial infections are common in pediatric patients.
  • Effective and safe antimicrobial agents are crucial for treating pediatric infections.
  • Cefprozil is a cephalosporin antibiotic with a broad spectrum of activity.

Purpose of the Study:

  • To evaluate the clinical efficacy and safety of cefprozil granule preparation in pediatric patients with bacterial infections.
  • To assess the bacteriological eradication rates of cefprozil against common pediatric pathogens.

Main Methods:

  • Oral administration of cefprozil granule preparation to 16 pediatric patients (8 months to 9 years 6 months).
  • Daily doses ranged from 29.4 to 35.7 mg/kg, divided into 3 or 4 doses.

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  • Clinical efficacy, bacteriological response, and adverse events were monitored.

    • Main Results:

    • Overall clinical efficacy rate was 100% (9 excellent, 7 moderate).
    • Bacteriological eradication rate was 68.8% against 17 pathogen strains, including Haemophilus influenzae, Streptococcus pyogenes, and Staphylococcus aureus.
    • No significant side effects were observed; abnormal laboratory findings were transient and not clinically significant.
    • Palatability was not an issue, with no drug refusal due to taste or odor.

    Conclusions:

    • Cefprozil granule preparation is highly effective and well-tolerated for treating pediatric bacterial infections.
    • The drug demonstrated a favorable safety profile and good palatability in the pediatric population.
    • Cefprozil shows promise as a valuable therapeutic option for pediatric bacterial infections.