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Online human conjunctival vessel diameter analysis. A clinical-methodical study.

Edgar Nagel¹, Walthard Vilser, Ines Lanzl

¹e_a_nagel@t-online.de

Clinical Hemorheology and Microcirculation

|August 5, 2003

Summary

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A new method uses a retinal vessel analyzer to precisely measure changes in conjunctival vessel diameter. This non-invasive technique accurately assesses drug effects on conjunctival vessels.

Area of Science:

Ophthalmology
Medical Devices
Pharmacology

Background:

Assessing conjunctival vessels is crucial for understanding ocular drug effects.
Commercially available retinal vessel analysis devices offer potential for conjunctival vessel assessment.

Purpose of the Study:

To evaluate the application of an on-line measuring device for retinal vessels in assessing conjunctival vessels.
To determine the precision and reliability of this technique for measuring conjunctival vessel diameter changes.

Main Methods:

11 healthy volunteers underwent repeated measurements of conjunctival vessels using the Retinal Vessel Analyzer (RVA).
Measurements were taken before and after topical vasoconstrictor application.
The RVA system automatically determined on-line vessel diameter changes.

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Main Results:

High precision was demonstrated with an intraclass correlation coefficient of 0.97 and a mean variation coefficient of 1.8% without vasoconstrictor.
Topical vasoconstrictor induced initial vasodilation (+10.9%) followed by significant vasoconstriction (-12.0% at 4 min).
One participant was excluded due to unmeasurable baseline conjunctival vessels.

Conclusions:

The RVA technique provides highly precise measurements of conjunctival vessel diameter changes.
This non-invasive method is suitable for assessing the effects of topical and systemic drugs on conjunctival vessels.